Research Articles 3
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Comparison of Keratinocyte and Myeloid Transcriptional Phenotypes and Shared Candidate Features Between Acute Irritant and Allergic Contact Dermatitis Based on Single-Cell RNA Sequencing
This study compared the transcriptional phenotypes of keratinocytes (KCs) and the myeloid compartment after exposure in acute irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), and identified c... -
Methodological exploration of cross-platform single-cell comparison and joint exploratory analysis of IgG4-ROD
Using the same reproducible pipeline, this study examined how merging and filtering strategies in cross-platform single-cell comparison alter functional enrichment conclusions, and accordingly proposed actionable pra... -
Hypertension as a Common Cause of Ulcerative Colitis, Intracerebral Hemorrhage, and Major Depressive Disorder: A Causal Inference Study Integrating Cross-Sectional Analysis, Bidirectional Mendelian Randomization, and Drug-Target Genetic Proxies
Patients with intracerebral hemorrhage (ICH) are often observed to have comorbid ulcerative colitis (UC), but whether this reflects a direct causal relationship or confounding by a common cause remains unclear. We ai...
Literature Reviews 2
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Differences in Sensitivity to Alcohol Exposure Among Liver Function Indicators and Their Methodological Impact on Dose-Response Research in ALD
Dose-response studies in alcohol-related liver disease (ALD) vary widely in their choice of effect indicators, making low-risk drinking thresholds difficult to compare across studies. This narrative review examines r... -
Mechanistic Basis for the Applicability of Animal Models in Diabetic Wound Therapy: A Comparative Analysis of Animal and Human Data
Diabetic foot ulcers (DFUs) are a major clinical and economic burden. Animal models of diabetic wounds are key preclinical tools for developing drugs and therapies. However, their clinical predictive value has long b...