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Medicine, Health and Clinical Practice is a comprehensive medical journal focusing on innovation in medical research and its application in clinical practice. Guided by its mission to “promote the translation of medical research, facilitate the exchange of clinical experience and serve the development of health care”, the journal is committed to building a platform for academic exchange and knowledge sharing among health care professionals, medical researchers and health management practitioners.
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Research Articles
Comparison of Keratinocyte and Myeloid Transcriptional Phenotypes and Shared Candidate Features Between Acute Irritant and Allergic Contact Dermatitis Based on Single-Cell RNA Sequencing
This study compared the transcriptional phenotypes of keratinocytes (KCs) and the myeloid compartment after exposure in acute irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD), and identified c... -
Research Articles
Methodological exploration of cross-platform single-cell comparison and joint exploratory analysis of IgG4-ROD
Using the same reproducible pipeline, this study examined how merging and filtering strategies in cross-platform single-cell comparison alter functional enrichment conclusions, and accordingly proposed actionable pra... -
Research Articles
Hypertension as a Common Cause of Ulcerative Colitis, Intracerebral Hemorrhage, and Major Depressive Disorder: A Causal Inference Study Integrating Cross-Sectional Analysis, Bidirectional Mendelian Randomization, and Drug-Target Genetic Proxies
Patients with intracerebral hemorrhage (ICH) are often observed to have comorbid ulcerative colitis (UC), but whether this reflects a direct causal relationship or confounding by a common cause remains unclear. We ai... -
Literature Reviews
Differences in Sensitivity to Alcohol Exposure Among Liver Function Indicators and Their Methodological Impact on Dose-Response Research in ALD
Dose-response studies in alcohol-related liver disease (ALD) vary widely in their choice of effect indicators, making low-risk drinking thresholds difficult to compare across studies. This narrative review examines r... -
Literature Reviews
Mechanistic Basis for the Applicability of Animal Models in Diabetic Wound Therapy: A Comparative Analysis of Animal and Human Data
Diabetic foot ulcers (DFUs) are a major clinical and economic burden. Animal models of diabetic wounds are key preclinical tools for developing drugs and therapies. However, their clinical predictive value has long b...
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